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Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed. The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, September 19th 2022
Conclusion Use of the Khavinson peptides and melatonin in combination in this way, at this dose, negatively impacts the thymus, producing a reduction in active tissue and increase in atrophy to fatty tissue. The degree to which this atrophy occurred is greater than one would expect to take place over nine months of aging at this stage of life. Why did this outcome occur, given the animal studies showing thymic regrowth, and the studies showing reduced later life mortality following use of thymogen? We can only speculate. Firstly, the dose makes the poison, and the dosing here may have been too high, too frequ...
Source: Fight Aging! - September 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Spotlight on therapeutic efficiency of mesenchymal stem cells in viral infections with a focus on COVID-19
Stem Cell Res Ther. 2022 Jun 17;13(1):257. doi: 10.1186/s13287-022-02944-7.ABSTRACTThe SARS-COV-2 virus has infected the world at a very high rate by causing COVID-19 disease. Nearly 507 million individuals have been infected with this virus, with approximately 1.2% of these patients being dead, indicating that this virus has been out of control in many countries. While researchers are investigating how to develop efficient drugs and vaccines versus the COVID-19 pandemic, new superseded treatments have the potential to reduce mortality. The recent application of mesenchymal stem cells (MSCs) in a subgroup of COVID-19 patie...
Source: Cancer Control - June 17, 2022 Category: Cancer & Oncology Authors: Saman Yasamineh Hesam Ghafouri Kalajahi Pooneh Yasamineh Omid Gholizadeh Hamed Rahmani Youshanlouei Saeed Karimi Matloub Masoud Mozafari Elham Jokar Yalda Yazdani Mehdi Dadashpour Source Type: research

Mesenchymal Stromal Cells and their EVs as potential leads for SARS-CoV2 treatment
Curr Stem Cell Res Ther. 2022 Apr 26. doi: 10.2174/1574888X17666220426115831. Online ahead of print.ABSTRACTIn December 2019, a betacoronavirus was isolated from pneumonia cases in China and rapidly turned into a pandemic of COVID-19. The virus is an enveloped positive-sense ssRNA and causes a severe respiratory syndrome along with a cytokine storm, which is the main cause of most complications. Therefore, treatments that can effectively control the inflammatory reactions are necessary. Mesenchymal Stromal Cells and their EVs are well-known for their immunomodulatory effects, inflammation reduction, and regenerative potent...
Source: Current Stem Cell Research and Therapy - April 27, 2022 Category: Stem Cells Authors: Vahid Kia Reza Eshaghi-Gorji Reyhaneh Nassiri Mansour Hadi Hassannia Elham Hasanzadeh Mobina Gheibi Amir Mellati Seyed Ehsan Enderami Source Type: research

Potential effect of amniotic fluid-derived stem cells on hyperoxia-induced pulmonary alveolar injury
CONCLUSIONS: Amniotic fluid-mesenchymal stem cells showed promising protective and therapeutic results against hyperoxia-induced lung fibrosis as evaluated physiologically, histologically and biochemically.PMID:35379329 | DOI:10.1186/s13287-022-02821-3
Source: Cell Research - April 5, 2022 Category: Cytology Authors: Amany Solaiman Radwa A Mehanna Ghada A Meheissen Soha Elatrebi Rasha Said Nahed H Elsokkary Source Type: research

Therapeutic strategies for COVID-19 patients: An update
Infect Disord Drug Targets. 2022 Mar 22. doi: 10.2174/1871526522666220322145729. Online ahead of print.ABSTRACTThe novel coronavirus SARS-coV-2, which emerged in Wuhan in November 2019, has increasingly spread causing a global pandemic that infected more than 444 million people, resulting in severe social and economic ramifications, and claimed more than 6,010,000 lives by March 5, 2022. The pandemic attracted global attention with consequential multiple economic, social, and clinical studies. Among causes of poor clinical outcome of the disease are therapeutic challenges, leading to spirals of studies in search for better...
Source: Infectious Disorders Drug Targets - March 23, 2022 Category: Infectious Diseases Authors: Muhammad Ibrahim Getso Soudabeh Etemadi Vahid Raissi Moein Mohseni Maedeh Sadat Mohseni Farid Raeisi Omid Raiesi Source Type: research

Long-term survivors following autologous haematopoetic stem cell transplantation have significant defects in their humoral immunity against vaccine preventable diseases, years on from transplant
Vaccine. 2021 Jul 19:S0264-410X(21)00881-1. doi: 10.1016/j.vaccine.2021.07.022. Online ahead of print.ABSTRACTCurrent international guidelines recommend routinely vaccinating haematopoetic stem cell transplant (HSCT) recipients. Despite significant infection-related mortality following autologous HSCT, routine vaccination programmes (RVP) completion is poor. For recovered HSCT recipients, it is uncertain whether catch-up vaccination remains worthwhile years later. To determine potential susceptibility to vaccine preventable infections, we measured antibody titres in 56 patients, a median of 7 years (range 0-29) following a...
Source: Vaccine - July 23, 2021 Category: Allergy & Immunology Authors: Hayley Colton Diana M Greenfield John A Snowden Paul D E Miller Nicholas J Morley Josh Wright Thomas C Darton Cariad M Evans Thushan I de Silva Source Type: research

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